Entrez 1108 | Ensembl ENSG00000111642 | |
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Aliases CHD4, CHD-4, Mi-2b, Mi2-BETA, chromodomain helicase DNA binding protein 4 External IDs MGI: 1344380 HomoloGene: 68175 GeneCards: CHD4 | ||
Chromodomain-helicase-DNA-binding protein 4 is an enzyme that in humans is encoded by the CHD4 gene.
Contents
Function
The product of this gene belongs to the SNF2/RAD54 helicase family. It represents the main component of the nucleosome remodeling and deacetylase complex and plays an important role in epigenetic transcriptional repression. Patients with dermatomyositis develop antibodies against this protein.
Interactions
CHD4 has been shown to interact with HDAC1, Histone deacetylase 2, MTA2, SATB1 and Ataxia telangiectasia and Rad3 related.
References
CHD4 Wikipedia(Text) CC BY-SA