Entrez 1107 | Ensembl ENSG00000170004 | |
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Aliases CHD3, Mi-2a, Mi2-ALPHA, ZFH, chromodomain helicase DNA binding protein 3 External IDs MGI: 1344395 HomoloGene: 62693 GeneCards: CHD3 | ||
Chromodomain-helicase-DNA-binding protein 3 is an enzyme that in humans is encoded by the CHD3 gene.
Contents
Function
This gene encodes a member of the CHD family of proteins which are characterized by the presence of chromo (chromatin organization modifier) domains and SNF2-related helicase/ATPase domains. This protein is one of the components of a histone deacetylase complex referred to as the Mi-2/NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Chromatin remodeling is essential for many processes including transcription. Autoantibodies against this protein are found in a subset of patients with dermatomyositis. Three alternatively spliced transcripts encoding different isoforms have been described.
Interactions
CHD3 has been shown to interact with: