Species Human Entrez 11140 | Human Mouse Ensembl ENSG00000105401 | |
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Aliases CDC37, P50cell division cycle 37 External IDs MGI: 109531 HomoloGene: 38268 GeneCards: CDC37 | ||
Hsp90 co-chaperone Cdc37 is a protein that in humans is encoded by the CDC37 gene.
Contents
The protein encoded by this gene is highly similar to Cdc 37, a cell division cycle control protein of Saccharomyces cerevisiae. This protein is a molecular chaperone with specific function in cell signal transduction. It has been shown to form complex with Hsp90 and a variety of protein kinases including CDK4, CDK6, SRC, RAF1, MOK, as well as eIF-2 alpha kinases. It is thought to play a critical role in directing Hsp90 to its target kinases.
Interactions
CDC37 has been shown to interact with:
Domain architecture
CDC37 consists of three structural domains. The N-terminal domain binds to protein kinases. The central domain is the Hsp90 chaperone (heat shock protein 90) binding domain. The function of the C-terminal domain is unclear.