Symbol SLC3A2 HUGO 11026 RefSeq NM_001013251 | Entrez 6520 OMIM 158070 | |
Alt. symbols MDU1, 4T2HC, 4F2, NACAE, CD98 |
CD98 is a glycoprotein that is a heterodimer composed of SLC3A2 and SLC7A5 that forms the large neutral amino acid transporter (LAT1). LAT1 is a heterodimeric membrane transport protein that preferentially transports branched-chain (valine, leucine, isoleucine) and aromatic (tryptophan, tyrosine) amino acids. LAT is highly expressed in brain capillaries (which form the blood–brain barrier) relative to other tissues.
A functional LAT1 transporter is composed of two proteins encoded by two distinct genes:
References
CD98 Wikipedia(Text) CC BY-SA