Entrez 939 | Ensembl ENSG00000139193 | |
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Aliases CD27, S152, S152. LPFS2, T14, TNFRSF7, Tp55, CD27 molecule External IDs OMIM: 186711 MGI: 88326 HomoloGene: 74386 GeneCards: CD27 | ||
CD27 is a member of the tumor necrosis factor receptor superfamily. It is currently of interest to immunologists as a co-stimulatory immune checkpoint molecule.
Contents
Function
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is required for generation and long-term maintenance of T cell immunity. It binds to ligand CD70, and plays a key role in regulating B-cell activation and immunoglobulin synthesis. This receptor transduces signals that lead to the activation of NF-κB and MAPK8/JNK. Adaptor proteins TRAF2 and TRAF5 have been shown to mediate the signaling process of this receptor. CD27-binding protein (SIVA), a proapoptotic protein, can bind to this receptor and is thought to play an important role in the apoptosis induced by this receptor.
As a drug target
Varlilumab is an antibody that binds to CD27 and is an experimental cancer treatment.
Interactions
CD27 has been shown to interact with SIVA1, TRAF2 and TRAF3.