Species Human Entrez 6351 | Human Mouse Ensembl n/a | |
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Aliases CCL4, ACT2, AT744.1, G-26, HC21, LAG-1, LAG1, MIP-1-beta, MIP1B, MIP1B1, SCYA2, SCYA4, C-C motif chemokine ligand 4 External IDs OMIM: 182284 MGI: 98261 HomoloGene: 48153 GeneCards: CCL4 | ||
Chemokine (C-C motif) ligand 4, also known as CCL4, is a protein which in humans is encoded by the CCL4 gene.
Contents
Function
CCL4, also known as Macrophage inflammatory protein-1β (MIP-1β) is a CC chemokine with specificity for CCR5 receptors. It is a chemoattractant for natural killer cells, monocytes and a variety of other immune cells.
CCL4 is a major HIV-suppressive factor produced by CD8+ T cells.
Perforin-low memory CD8+ T cells that normally synthesize MIP-1-beta.
Interactions
CCL4 has been shown to interact with CCL3.
References
CCL4 Wikipedia(Text) CC BY-SA