Neha Patil (Editor)

CBLB (gene)

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Species
  
Entrez
  
868

Human
  
Ensembl
  
ENSG00000114423

CBLB (gene)

Aliases
  
CBLB, Cbl-b, RNF56, Nbla00127, Cbl proto-oncogene B

External IDs
  
MGI: 2146430 HomoloGene: 15856 GeneCards: CBLB

CBL-B is an E3 ubiquitin-protein ligase that in humans is encoded by the CBLB gene. CBLB is a member of the CBL gene family.

Contents

Function

CBL-B functions as a negative regulator of T-cell activation. CBL-B expression in T cells causes ligand-induced T cell receptor down-modulation, controlling the activation degree of T cells during antigen presentation.

Clinical significance

Mutation of the CBLB gene has been associated with autoimmune conditions such as type 1 diabetes.

Interactions

CBLB has been shown to interact with:

  • CRKL,
  • Epidermal growth factor receptor,
  • Grb2,
  • NEDD4,
  • PIK3R1, and
  • SH3KBP1.
  • References

    CBLB (gene) Wikipedia


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