Species Human Entrez 868 | Human Mouse Ensembl ENSG00000114423 | |
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Aliases CBLB, Cbl-b, RNF56, Nbla00127, Cbl proto-oncogene B External IDs MGI: 2146430 HomoloGene: 15856 GeneCards: CBLB | ||
CBL-B is an E3 ubiquitin-protein ligase that in humans is encoded by the CBLB gene. CBLB is a member of the CBL gene family.
Contents
Function
CBL-B functions as a negative regulator of T-cell activation. CBL-B expression in T cells causes ligand-induced T cell receptor down-modulation, controlling the activation degree of T cells during antigen presentation.
Clinical significance
Mutation of the CBLB gene has been associated with autoimmune conditions such as type 1 diabetes.
Interactions
CBLB has been shown to interact with:
References
CBLB (gene) Wikipedia(Text) CC BY-SA