Entrez 29775 | Ensembl ENSG00000100065 | |
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Aliases CARD10, BIMP1, CARMA3, caspase recruitment domain family member 10 External IDs MGI: 2146012 HomoloGene: 8728 GeneCards: CARD10 | ||
Caspase recruitment domain-containing protein 10 is an enzyme that in humans is encoded by the CARD10 gene.
Contents
Function
The caspase recruitment domain (CARD) is a protein module that consists of 6 or 7 antiparallel alpha helices. It participates in apoptosis signaling through highly specific protein-protein homophilic interactions. CARDs induce nuclear factor kappa-B (NF-κB; MIM 164011) activity through the IKK (e.g., IKBKB; MIM 603258) complex. CARD9 (MIM 607212), CARD10, CARD11 (MIM 607210), and CARD14 (MIM 607211) interact with BCL10 (MIM 603517) and are involved in NF-κB signaling complexes. Except for CARD9, these CARD proteins are members of the membrane-associated guanylate kinase (MAGUK) family.[supplied by OMIM]
Interactions
CARD10 has been shown to interact with BCL10.