Aliases C14orf159 Human Mouse Ensembl ENSG00000133943 | Species Human Entrez 80017 | |
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External IDs MGI: 2444813 HomoloGene: 11798 GeneCards: C14orf159 | ||
UPF0317 protein C14orf159, mitochondrial is a protein that in humans is encoded by the C14orf159 gene (chromosome 14 open reading frame 159).
Contents
Orthologs
The human gene, c14orf159 mRNA, is highly conserved in mammals and birds. Orthologs gathered from BLAST and BLAT searches reveal that the human c14orf159 mRNA sequence is conserved with a sequence identity of 98% in chimpanzees, 88% in mice, and 81% in platypus and chicken. The following table contains a list orthologs that were gathered from BLAST searches. Sequence alignments were performed using blastn to derive sequence identity, score, and E-values between the human c14orf159 variant 1 mRNA and its orthologs.
Human C14orf159 Orthologs-mRNA
The protein that the human gene c14orf159 encodes has been found to be highly conserved among mammals, birds, amphibians, fish, tunicates, cnidarians, and echinoderms. However, no protein orthologs have been found in nematodes, arthropods, fungi, protists, plants, bacteria, or archea. Fungi and bacteria contain the DUF1445 conserved domain which is found in human c14orf159 and its orthologs. BLAST and BLAT searches have been utilized to find orthologs to the c14orf159 protein. The following table lists protein orthologs for the human protein with sequence identity, sequence similarity, scores, and E-values derived from blastp sequence comparisons.
Post-translational modification
The protein product of the C14orf159 gene is predicted and was found to be translocated to mitochondrion.
Post-translational modifications are predicted for the protein c14orf159. All predicted sites in human c14orf159 were compared to orthologs using multiple sequence alignments to determine likelihood of modification.
Regulation
Estrogen receptor alpha, in the presence of estradiol, binds to the C14orf159 gene and likely regulates its expression.