C type lectin

Updated on Oct 26, 2023

Edit

Comment

Symbol Lectin_C InterPro IPR001304 PROSITE PS50041		Pfam PF00059 SMART CLECT SCOP 2msb

A C-type lectin (CLEC) is a type of carbohydrate-binding protein domain known as a lectin. The C-type designation is from their requirement for calcium for binding. Proteins that contain C-type lectin domains have a diverse range of functions including cell-cell adhesion, immune response to pathogens and apoptosis.

Classification

Drickamer et al. classified C-type lectins into 7 subgroups (I to VII) based on the order of the various protein domains in each protein. This classification was subsequently updated in 2002, leading to seven additional groups (VIII to XIV). Most recently, three further subgroups were added (XV to XVII).

CLECs include:

CLEC1A, CLEC1B

CLEC2A, CLEC2B, CD69 (CLEC2C), CLEC2D, CLEC2L

CLEC3A, CLEC3B

CLEC4A, CLEC4C, CLEC4D, CLEC4E, CLEC4F, CLEC4G, ASGR1 (CLEC4H1), ASGR2 (CLEC4H2), FCER2 (CLEC4J), CD207 (CLEC4K), CD209 (CLEC4L), CLEC4M

CLEC5A

CLEC6A

CLEC7A

OLR1 (CLEC8A)

CLEC9A

CLEC10A

CLEC11A

CLEC12A, CLEC12B

CD302 (CLEC13A), LY75 (CLEC13B), PLA2R1 (CLEC13C), MRC1 (CLEC13D), MRC2 (CLEC13E)

CLEC14A

CLEC16A

CLEC17A

The "NK Cell lectin-like receptors" are a very closely related group:

KLRA1

KLRB1 (CLEC5B)

KLRC1, KLRC2, KLRC3, KLRC4

KLRD1

KLRF1 (CLEC5C)

KLRG1 (CLEC15A), KLRG2 (CLEC15B)

KLRK1

Additional proteins containing this domain include:

AGC1; ATRNL1

BCAN

CD248; CD72; CD93; CHODL; CL-K1-Ia; CL-K1-Ib; CL-K1-Ic; CLECSF5; COLEC10; COLEC11; COLEC12; CSPG3

FCER2; FREM1; HBXBP;

LAYN; LOC348174; LOC728276

MAFA; MBL2; MGC34761; MICL; MRC1L1

OLR1

PAP; PKD1; PKD1L2; PLA2R1; PRG2; PRG3

REG1A; REG1B; REG3A; REG3G; REG4

SELE; SELL; SELP; SFTPA1; SFTPA2; SFTPA2B; SFTPD; SRCL

THBD

VCAN

References

C-type lectin Wikipedia

(Text) CC BY-SA