Species Human Entrez 5967 | Human Mouse Ensembl ENSG00000115386 | |
 | ||
Aliases REG1A, ICRF, P19, PSP, PSPS, PSPS1, PTP, REG, regenerating family member 1 alpha External IDs MGI: 97895 HomoloGene: 68282 GeneCards: REG1A | ||
Lithostathine-1-alpha also known as islet cells regeneration factor (ICRF) or islet of Langerhans regenerating protein (REG) is a protein that in humans is encoded by the REG1A gene.
Function
This protein is a type I subclass member of the Regenerating protein family. The Reg protein family is a multi protein family grouped into four subclasses, types I, II, III and IV based on the primary structures of the proteins. This protein that is secreted by the exocrine pancreas. It is associated with islet cell regeneration and diabetogenesis and may be involved in pancreatic lithogenesis. Reg family members REG1B, REGL, PAP and this gene are tandomly clustered on chromosome 2p12 and may have arisen from the same ancestral gene by gene duplication.
References
REG1A Wikipedia(Text) CC BY-SA