Entrez 130120 | Ensembl ENSG00000143954 | |
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Aliases REG3G, LPPM429, PAP IB, PAP-1B, PAP1B, PAPIB, REG III, REG-III, UNQ429, regenerating family member 3 gamma External IDs MGI: 109406 HomoloGene: 128216 GeneCards: REG3G | ||
Regenerating islet-derived protein 3 gamma (also Regenerating islet-derived protein III-gamma) is a protein that in humans is encoded by the REG3G gene.
Intestinal paneth cells produce REG3G (or REG3 gamma) via stimulation of toll-like receptors (TLRs) by pathogen-associated molecular patterns (PAMPs). REG3 gamma specifically targets Gram-positive bacteria because it binds to their surface peptidoglycan layer. It is one of several antimicrobial peptides produced by paneth cells.
References
REG3G Wikipedia(Text) CC BY-SA