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Burkhard Rost

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Name  Burkhard Rost
Doctoral advisor  Chris Sander
Education  Heidelberg University
Burkhard Rost httpsiytimgcomvimqPsNazEipAhqdefaultjpg
Born  July 11, 1961 (age 54) Germany (1961-07-11)
Institutions  Technische Universitat Munchen (TUM) Ludwig Maximilian University of Munich (LUM) Columbia University University of Heidelberg European Molecular Biology Laboratory
Alma mater  University of Heidelberg
Thesis  Neural networks and evolution - advanced prediction of protein secondary structure (1994)
Doctoral students  Yana Bromberg Jinfeng Liu Yana Ofran Avner Schlessinger
Known for  Presidency of ISCB Organisation of ISMB, CASP Predictprotein combination of evolutionary information and machine learning
Notable awards  Alexander von Humboldt Professor, ISCB Fellows Award
Fields  Machine learning, Evolution, Bioinformatics

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Burkhard Rost is a scientist leading the Department for Computational Biology & Bioinformatics at the Faculty of Informatics of the Technical University of Munich (TUM). Rost chairs the Study Section Bioinformatics Munich involving the TUM and the Ludwig Maximilian University of Munich (LMU) in Munich. Since 2007 Rost has been the President of the International Society for Computational Biology (ISCB).


Computational biologist prof burkhard rost


Rost originally started his scientific career as theoretical physicist. After studying physics at the University of Giessen and physics, history, philosophy, and psychology at the University of Heidelberg, Rost received his PhD at the University Heidelberg for his work at the European Molecular Biology Laboratory (EMBL) in 1994. Following research internships at EMBL and the European Bioinformatics Institute in Cambridge (UK), in 1998, he became assistant professor at the Department of Biochemistry and Molecular Biophysics in the College of Surgeons and Physicians of the CU Medical Center of Columbia University in the City of New York. In 2000, he became associate professor at Columbia University and in 2009 he accepted an appointment to the Chair of Bioinformatics at the Technical University of Munich. He is a member of the New York Academy of Sciences and has been President of ISCB, the International Society for Computational Biology from 2007-2014. As of 2011, Rost has authored or co-authored over 200 scientific publications with an Google-Scholar h-index of 79.


Rost research has focused on combining Machine Learning and evolutionary information to predict aspects of critical importance to advance our understanding of evolution, protein structure and protein function. Examples of research carried out in his lab includes the prediction of enzymatic activity (ECGO), interaction partners (ISIS, DISIS, PiNAT), subcellular localization (LOCtree, LOCnet, PredictNLS), functional effects of point mutations/SNPs (SNAP), disordered regions (MD, NORSnet, Ucon), membrane spanning segments (PROF/PHDhtm), secondary structure (PROF/PHD, RePROF, DSSPcont), solvent accessibility (PROF/PHD, RePROF), internal residue-residue contacts (PROFcon) and the clustering of proteins into families (CHOP).

The his current focus is on predicting the effects of individual mutations mostly on the level of non-synonymous changes in coding regions, i.e. single nucleotide changes (or Single Nucleotide Polymorphisms that alter the amino acid sequence.

His group has been dedicated to making their tools available online as demonstrated through the first internet server for protein structure prediction and sequence analysis, Predictprotein, that was launched in 1992, and has been continuously in service ever since. Rost's work has been published in leading peer reviewed scientific journals including Nature, Science, PLOS Genetics.


Rost has been President of the professional international organization in computational biology and bioinformatics , the International Society for Computational Biology (ISCB) since 2007. He will continue to serve until 2014.


Rost has co-chaired the largest annual meeting in computational biology ISMB, Intelligent Systems for Molecular Biology, in 2007 (Vienna), 2008 (Toronto), 2011 (Vienna), 2012 (Long Beach). He has initiated and been involved in the organization of several series of international conferences outside the usual northern hemisphere, namely the ISCB Africa (2010: Bamako, Mali; 2011: Cape Town, South Africa; 2013: Tunis, Tunisia) in cooperation with the [ African Society for Computational Biology and Bioinformatics ASBCB], the ISCB Latin America (2010: Montevideo, Uruguay; 2012: Santiago de Chile, Chile; 2014: Rio de Janeiro, Brazil), and most recently the ISCB Asia (2011: Kuala Lumpur, Malaysia; 2012: Shen Zhen, China).

Rost has also been a co-organizer of the Critical Assessment of protein Structure Prediction (CASP) meetings from 2002-2008 (CASP4-CASP8).

Awards and honors

Rost was awarded the Professorship of the Alexander von Humboldt Foundation in 2009. He was made a Fellow of the ISCB in 2015.


Burkhard Rost Wikipedia

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