ATC code C07AA19 (WHO) Biological half-life 2-4 hours (plasma) Protein binding 76% | Bioavailability < 10% Molar mass 271.783 g/mol | |
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AHFS/Drugs.com International Drug Names Routes ofadministration Oral, topical (eye drops) Metabolism | ||
Medical vocabulary what does bupranolol mean
Bupranolol is a non-selective beta blocker without intrinsic sympathomimetic activity (ISA), but with strong membrane stabilizing activity. Its potency is similar to propranolol.
Contents
- Medical vocabulary what does bupranolol mean
- How to pronounce bupranolol
- Uses and dosage
- Pharmacology
- Adverse effects contraindications interactions
- References
How to pronounce bupranolol
Uses and dosage
Like other beta blockers, oral bupranolol can be used to treat hypertension and tachycardia. The initial dose is 50 mg two times a day. It can be increased to 100 mg four times a day. Bupranolol eye drops (0.05%-0.5%) are used against glaucoma.
Pharmacology
Bupranolol is quickly and completely absorbed from the gut. Over 90% undergo first-pass metabolism. Bupranolol has a plasma half life of about two to four hours, with levels never reaching 1 µg/l in therapeutic doses. The main metabolite is carboxybupranolol, 4-chloro-3-[3-(1,1-dimethylethylamino)-2-hydroxy-propyloxy]benzoic acid – that is, the methyl group at the benzene ring is oxidized to a carboxyl group –, of which 88% are eliminated renally within 24 hours.
Adverse effects, contraindications, interactions
Adverse effects, contraindications and interactions are similar to other beta blockers.