Carruth was born and raised in Athens, Georgia, United States. She is the third of seven children.
As a teenager, Carruth was a size 3 in jeans and weighed 119 pounds. She visited a nutritionist and started drinking supplement shakes to gain weight In 2001, she started gaining weight up to 180 pounds, and then down to her current weight of 173 pounds.
In 2004, while in Baltimore, Maryland, Carruth met a photographer at a club. She hired him to do a swimsuit photo shoot at her hotel, intending the photos as a gift for her boyfriend. However, without her knowledge or consent, the photographer posted the pictures online. The photographer then sent her links to the different websites where the pictures were featured. In February 2004, the pictures were posted on a Yahoo group, and within a week 20,000 people signed up to view them. Carruth was subsequently contacted by rapper Tony Yayo.
Within a four-month period, Carruth appeared as a video vixen in the music video for Tony Yayo and 50 Cent's So Seductive", and was featured in magazine layouts for King, XXL and Black Men Magazine. In April 2005, she launched and expanded her website: BuffietheBody.com, where she did swimsuit modeling, which attracted considerable interest on the Internet.
After her debut in the "So Seductive" video she received offers for magazine spreads, leads in music videos, requests for guest appearances. She also shot a biographical DVD. She appeared in the music video for Juelz Santana's "Oh Yes". In a year she had appeared in 60 magazines and news articles.
Carruth has appeared several times in Black Men, Black Men SSX, Smooth, Vibe, XXL, King, The Source. In 2012, she reported that Black Men SSX was the Only magazine that paid her.
In 2006, Carruth played the role of Big Booty Judy in the film ATL. In 2008, she appeared in the independent dramatic-thriller film, Subtle Seduction.
In August 2006, Buffie the Body Presents Larger Than Life DVD was released, which featured memorable moments from her career. In January 2007, Buffie the Body – In your Dreams: The Making of the 2007 Calendar DVD was released.
Carruth has worked on a hip-hop talk show based in Atlanta. In 2007, she appeared on The Tyra Banks Show discussing her body's transformation. In June 2008, she shot a pilot for a reality show with Vida Guerra.
Carruth has worked as a columnist for Black Mens Magazine called "Sex, Love and Relationships".
In 2008, she published an e-book titled Get Your Mind Right: A Step-By-Step Look at the Modeling Career of Buffie the Body". On June 1, 2009, she released her autobiography Vixen Icon.
In 2007, Carruth launched a health and fitness website. In 2012, she became a Certified Personal Trainer (CPT) through The National Academy of Sports Medicine. In August 2013, Carruth released fitness DVD Grade A Glutes.
Carruth has been reported to charge between $2,500 to $3.500 for a public appearance. Carruth reportedly earns up to $10,000 a night hosting parties around the United States. She has hosted over 300–400 parties. She has also been booked outside of the United States in Amsterdam, Trinidad, and elsewhere.
In 2005, Buffie was named XXL's Eye Candy of the Year. She was nominated for the Vibe Video Goddess of the Year award for her appearance in Tony Yayo's "So Seductive" video. She was listed on Black Men magazine's 101 Sexiest Women.
In November 2005, Carruth's younger sister died of cancer. In 2012, her mother also died of cancer.
From 2005 to 2006, Carruth dated DJ Kay Slay. In 2015, she got married to John Lewis. She lives in South Carolina with her husband.
Carruth does not drink or smoke. She has a 45-inch sized hips with the word "Tasty" tattooed on her right buttock.
In 2006, Carruth got breast implants. In September 2012, she uploaded a video on YouTube revealing that her buttocks are real and not the product of injections, how much urban modeling paid, how female haters fueled her career, how online models are ruining the urban modeling industry, and why she left the urban modeling industry for the fitness industry.Carruth, Buffie. (2009). "Vixen Icon". Triple Crown Publications. 978-0091874759.Carruth, Buffie. (2008). "Get Your Mind Right: A Step-By-Step Look at the Modeling Career of Buffie the Body".Carruth, Buffie. (2013). "Why Flat Butts Stay Flat!: A detailed guide on building the glutes".