Formula C30H23BrO4 | ||
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How to pronounce bromadiolone
Bromadiolone is a potent anticoagulant rodenticide. It is a second-generation 4-hydroxycoumarin derivative and vitamin K antagonist, often called a "super-warfarin" for its added potency and tendency to accumulate in the liver of the poisoned organism. When first introduced to the UK market in 1980, it was effective against the populations that had become resistant to the first generation anticoagulants.
Contents
The product may be used both indoors and outdoors for rats and mice.
It is classified as an extremely hazardous substance in the United States as defined in Section 302 of the U.S. Emergency Planning and Community Right-to-Know Act (42 U.S.C. 11002), and is subject to strict reporting requirements by facilities which produce, store, or use it in significant quantities.
Toxicity
Bromadiolone can be absorbed through the digestive tract, through the lungs, or through skin contact. The pesticide is generally given orally. The substance is a vitamin K antagonist. The lack of vitamin K in the circulatory system reduces blood clotting and will cause death due to internal hemorrhaging.
Poisoning doesn't show up for 24 to 36 hours after poison is eaten and often it may take 2–5 days for the signs to show up.
Vitamin C is found in fruits and vegetables (commonly known as greens). Bromadiolone is an advanced type of Warfarin and interacts with Vitamin C. Increased Vitamin C in the blood may lead to greater exposure to the side-effects of the drug.
Following are acute LD50 values for various animals (mammals):
Chemistry
The compound is used as a mixture of four stereoisomers. Its two stereoisomeric centers are at the phenyl- and the hydroxyl-substituted carbons in the carbon chain of the substituent at the 3 position of the coumarin.
Antidote
Vitamin K1 is used as antidote.