Name Brian Matthews | Role Biochemist | |
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Institutions University of CambridgeUniversity of OregonHoward Hughes Medical Institute Known for Matthews correlation coefficient | ||
Brian matthews signing off from his final sounds of the 60s program on bbc radio 2
Brian W. Matthews is a biochemist and biophysicist educated at the University of Adelaide, contributor to x-ray crystallographic methodology at the University of Cambridge, and since 1970 at the University of Oregon as Professor of Physics and HHMI investigator in the Institute of Molecular Biology.
Contents
- Brian matthews signing off from his final sounds of the 60s program on bbc radio 2
- The fortunes here it comes again live bbc totps brian matthews 1st oct 65
- References
He created hundreds of mutants of T4 lysozyme (making it the commonest structure in the PDB), determined their structure by x-ray crystallography and measured their melting temperatures. Starting from questions about the basis of "temperature-sensitive" mutations, his work has explicated much about the general energetic and structural effects of mutations in proteins. He also solved early structures of the thermophilic bacterial enzyme thermolysin, the helix-turn-helix DNA-binding transcription factor lambda Cro repressor, and the light-antenna bacteriochlorophyll protein.
Beyond his contributions to biochemistry, Matthews is also known in the machine learning community for the Matthews correlation coefficient, which he introduced in a paper in 1975. The coefficient is used as a measure of the quality of binary (two-class) classifications.
Matthews has been a member of the National Academy of Sciences since 1986. He is the editor of the scientific journal Protein Science.