He began fighting in the United States, where his career picked up. On June 17, 2005 in Cabazon, California, he defeated Carlos Navarro for the WBC Continental Americas super featherweight title by a 7th-round technical knockout.
On June 10, 2006, he defended his title against former WBC featherweight titlist Kevin Kelley.
In a match held on November 16, 2006 to defend his title against Hector Velazquez, Bobby Pacquiao was stripped of his title for being three pounds over the weight limit. The fight was derided for careless performances from both Velazquez and Pacquiao. Referee Kenny Bayless warned Bobby Pacquiao ten times for performing too many low blows before he disqualified him in the eleventh round. As a result, Hector was rushed to the hospital after the fight.
Bobby Pacquiao made his debut at lightweight on June 9, 2007 where he fought soon-to-be WBC super featherweight champion Humberto Soto in a 10-round bout. After sustaining a wound that impaired his vision, he was knocked out in round 7.
Following three bouts in that division, Bobby Pacquiao knocked out Decho Bankluaygym in eight rounds on August 2, 2008 for the WBO Asia-Pacific lightweight title.
On November 19, 2008 he lost by unanimous decision to NABA champ Robert Frankel.Philippines Games & Amusement Board (GAB) Super Featherweight Title (2002)
WBC Continental Americas Super Featherweight Title (2005)
WBO Asia Pacific Lightweight Title (2008)
He was included in the 16-man roster that competed in SMART-Liga Pilipinas Conference II. On his debut,he scored only two points in a 63-59 loss to the Ilocos Sur Bravehearts. On January 16, 2009, he scored 10 points in a blow-out win against Zamboanga del Norte. He also wanted to play in the Tournament of the Philippines(TOP),the first joint project of Liga Pilipinas and the PBL but he was instead placed on the reserve list since Manny Pacquiao wanted to suit up for the team.
On May 27, 2014, it was reported that he was among those who tried out for KIA Motors which is coached by his brother Manny Pacquiao. His brother was asked if he will select Bobby,he answered that it will be too big of a favor to give. On July 26, 2014, in an interview with Snow Badua,he revealed that he will no longer apply for the 2014 PBA draft as he will focus instead on a possible stint with the family-supported CWBL franchise.
After the CWBL failed to materialize due to financial difficulties, he was then assigned as the team manager of Manny Pacquiao's PBA D-League Franchise.On the team's debut, they were handed a 27-point loss by Cafe France led by Maverick Ahanmisi who had ten points. The team last competed on the 2015 PBA D-League Foundation Cup.
Back in 2011,he and Manny played for the MP Warriors in the Manny Pacquiao Basketball Cup which featured teams such as BBEAL champion University of Baguio, runner-up University of the Cordilleras, Cordillera College from La Trinidad, Chesaa 2011 men’s basketball champion Baguio College of Technology. On one of the games, he scored 10 points while Manny scored 14.The tournament was staged in the middle of Manny Pacquiao's preparation against Shane Mosley. On March,2013, his team the MP Warriors then coached by Arvin Bonleon, won a P300 000 prize after defeating the Celebrity team lead by Gerald Anderson. In 2014,the MP Warriors, ruled the Kalilangan Festival Commercial basketball league in February by beating Kadayawan sa Dabaw Invitational Commercial champion Gold Star Davao. Pacquiao’s team also finished first runner-up in the Araw ng Dabaw Invitational Open league in March.
On October 19, 2013, he sought a seat in the village council of Labangal, where his wife, Lorelei is barangay head. He won and became village councilor of Barangay Labangal. His wife was also re-elected and as chairman of the same barangay. He ran under the People’s Champ Movement (PCM), a local political party founded by Manny Pacquiao. In May 2016, he got 95,052 votes and was proclaimed one of the 12 councilors of General Santos City.