Bay is a talented young rock drummer in Thailand in the 1970s. One day, he is practicing on his drum set in his apartment and is in a trance, but he suddenly notices that everything is covered in blood and that his drumsticks are actually knives. Apparently, he has killed his landlady, Mrs. Victoria. Panicked, he runs out his door, through the streets and alleys to his friend, Ton, who is also a drummer and is in a band called The PC with Meow and Ooh. Despite Bay's circuitous flight to Ton's apartment, she only lives next door to him.
Ton is a long-time childhood friend of Bay, as the two were classmates at Buddhist temple where they were instructed by an old monk in the Drums of the Gods.
Meanwhile, the police have arrived at Bay's apartment, led by Inspector Black Ears. The inspector has a habit of trying to kick in doors that open to the outside. Whenever the inspector yells "Damn!" (Batsop! in Thai), a man named Sombat appears and leans his head on the inspector's shoulder (sop means to lean on shoulder). The inspector also has a smart dog named Dumbass to sniff for clues.
Through his drumming, Bay is able to convince Meow and Ooh that he is innocent. Had he actually killed Mrs. Victoria, Bay would have broken one of the Buddhist precepts and his Drums of the Gods skills would no longer be effective. So they all go on the run and hide out from the cops.
Bay and The PC make their way to a village fair, where The PC has been booked to play. Meow and Ooh sit around and make Bay do all the work to set up the stage. When he's finished, they plan to call the cops on him anyway. Soon the cops do show up and a chase around the village fair ensues, with the inspector pursuing Bay on the various carnival rides. Just as it looks like Bay will escape, the inspector is given a rifle and proves that he is an expert marksman. Bay, however, manages to catch one of the bullets with his drumsticks, but another finds its mark in Bay's shoulder. Bay ends up getting away and finds himself on a dam overlooking a reservoir. On the dam, he meets a man who is going to commit suicide, but Bay talks him out of it. Bay is then picked up by a passing truck and makes his escape just as the inspector and his men have caught up. The inspector witnesses the drowning of his dog Dumbass and also meets a polite boy in a red shirt (meant to resemble tennis pro Paradorn Srichaphan).
Bay has been picked up by a truck hauling films to the village fair, and so he joins the film company and works as a dubber on the film. His performance is a hit, causing the audience to laugh their heads off. Afterward, Bay gives the man, who looks like Prime Minister Thaksin Shinawatra an idea to start a new political party called Thais Love Thais.
Bay is eventually caught and jailed. However, Ton and The PC are in jail, too. After Bay sings a sad song that makes everyone cry, Meow and Ooh decide to help Bay escape. They are able to rig up an explosion and Bay runs away with Ton. She sees that Bay is under stress and guesses it must be because of the upcoming battle of the Drums of the Gods vs the Devil's Drums. Bay's and Ton's teacher, Professor Tuengpo, faced the dark side drummer Ringo Starr in the last competition 10 years ago. He defeated Ringo but also died in the aftermath of the duel, before he could reveal to Bay and Don the secret of the crucial 10th level of the Drums of the Gods. In order to overcome the forces of evil, Bay or Ton must somehow achieve the elusive 10th level, and neither of them feel they are ready. Thinking perhaps that sex will help them achieve the level, they check into a shabby guesthouse and hole up in a room.
While in the guesthouse, which is very dirty, Bay complains to the owner, Mr. Chuwit, and tells him that the rooms should all have bathtubs so guests can clean up. This apparently gives Chuwit the idea to start a chain of massage parlors, all with bathtubs in the massage rooms.
The police again catch up with Bay who is knocked unconscious. When he comes to, the medical examiner tells him that the body of the person Bay is suspected of killing is not Mrs. Victoria, but the police won't consider the evidence. However, the ME lets Bay leave the room.
Bay finds the drumming duel and sees that it is Ton who will face the new Devil's Drums master, who is named Mr. Davis. Bay then realizes that the secret to the 10th level of drumming was the double-sexed technique, which means his penis was cut off and attached to Ton, giving her the power.
There is a climactic drumming duel in a boxing ring, in which all styles of drumming are explored, and the result is that the Drums of the Gods are victorious.Krissada Terrence as Bay
Nountaka Warawanitchanoun as Ton
Nimponth Chaisirikul as Inspector Black Ears
Nophadal Tavitumnusin as Meow
Pakapat Bunsomtom as Ooh
Pranee Keebut as Professor Tuengpo
Kiradej Ketakinta as Ringo Starr
Rang Sabian as Mr. Davis
Sumontha Suanpholaat as Mrs. Victoria
Sombat Metanee as Sombat