Group Group I (dsDNA) | ||
Similar Western barred bandicoot, Sulfolobus turreted icosahedr, Nudivirus, Corticovirus, Perameles | ||
Bandicoot papillomatosis carcinomatosis virus is a circular double stranded DNA virus isolated from bandicoots (Perameles bougainville). The genome has features similar to both the Papillomaviridae and the Polyomaviridae. Two species have been described to date.
Contents
Genome
The genome is ~7.5 kilobases in length with a G+C content of ~35%. Two structural genes are present: L1 and L2. The non structural genes are found on the opposite strand. The L1 gene encodes a protein with 506 residues and the L2 encodes a protein with 470 residues. The two non structural genes T (742 amino acid residues) and t (224 amino acid residues). The structural proteisn resemble those of the pappiloma viruses while the T and t antigens resemble those of the polyoma viruses.
Evolution
These viruses evolved via a recombination event between a papilloma virus and a polyoma virus between 10 million years ago and 50 million years ago.
Clinical
These viruses were isolated from and are thought to cause a progressively debilitating cutaneous and mucocutaneous papillomatosis and carcinomatosis syndrome. The lesions that occur in this disease are irregular thickenings and masses over the skin of the digits, body, pouch, and mucocutaneous junctions of the lips and conjunctiva. Cases have been described in both captive and wild individuals.
Genome sequences
The genome sequences can be found in GenBank with reference numbers
EU069819