Kalpana Kalpana (Editor)

BMPR1A

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Covid-19
Species  Human
Entrez  657
Human  Mouse
Ensembl  ENSG00000107779
BMPR1A httpsuploadwikimediaorgwikipediacommonsthu
Aliases  BMPR1A, 10q23del, ACVRLK3, ALK3, CD292, SKR5, bone morphogenetic protein receptor type 1A
External IDs  OMIM: 601299 MGI: 1338938 HomoloGene: 20911 GeneCards: BMPR1A

Gene music using protein sequence of bmpr1a bone morphogenetic protein receptor type ia


The bone morphogenetic protein receptor, type IA also known as BMPR1A is a protein which in humans is encoded by the BMPR1A gene. BMPR1A has also been designated as CD292 (cluster of differentiation 292).

Contents

Function

The bone morphogenetic protein (BMP) receptors are a family of transmembrane serine/threonine kinases that include the type I receptors BMPR1A (this protein) and BMPR1B and the type II receptor BMPR2. These receptors are also closely related to the activin receptors, ACVR1 and ACVR2. The ligands of these receptors are members of the TGF beta superfamily. TGF-betas and activins transduce their signals through the formation of heteromeric complexes with 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding.

BMP's repress WNT signaling to maintain stable stem cell populations. BMPR1A null mice died at embyonic day 8.0 without mesoderm specification, demonstrating its vital role in gastrulation. It has been demonstrated in experiments using dominant negative BMPR1A chick embryos that BMPR1A plays a role in apoptosis and adipocyte development. Using constitutively active forms of BMR1A it has been shown that it plays a role in cell differentiation. Signals tranduced by the BMPR1A receptor are not essential for osteoblast formation or proliferation; however, BMPR1A is necessary for the extracellular matrix deposition by osteoblasts. In the chick embryo, BMPR1A receptors are found in low levels in limb bud mesenchyme, a differing location to BMPR1B, supporting the differing roles they play in osteogenesis.

Ligands

  • Agonists: BMP2, BMP4, BMP6, BMP7, GDF6
  • Antagonists: Noggin, Chordin
  • Diseases

    BMPR1A, SMAD4 and PTEN are responsible for juvenile polyposis syndrome, juvenile intestinal polyposis and Cowden's disease.

    Interactions

    BMPR1A has been shown to interact with:

  • BMP2,
  • SF3B4, and
  • ZMYND11.
  • References

    BMPR1A Wikipedia


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