Species Human Entrez 64919 | Human Mouse Ensembl ENSG00000127152 | |
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Aliases BCL11B, ATL1, ATL1-alpha, ATL1-beta, ATL1-delta, ATL1-gamma, CTIP-2, CTIP2, RIT1, ZNF856B, hRIT1-alpha, B-cell CLL/lymphoma 11B External IDs MGI: 1929913 HomoloGene: 10974 GeneCards: BCL11B | ||
Gene music using protein sequence of bcl11b b cell cll lymphoma 11b zinc finger protein
B-cell lymphoma/leukemia 11B is a protein that in humans is encoded by the BCL11B gene.
Contents
Function
This gene encodes a C2H2-type zinc finger protein and is closely related to BCL11A, a gene whose translocation may be associated with B-cell malignancies. The specific function of this gene has not yet been determined, but it could also be involved in some malignancies. Two alternatively spliced transcript variants, which encode distinct isoforms, have been reported.
Recent research suggests that BCL11B is crucial for ameloblasts (the cells that produce tooth enamel) to form and work properly.
Interactions
BCL11B has been shown to interact with COUP-TFI.
References
BCL11B Wikipedia(Text) CC BY-SA