Trisha Shetty (Editor)

B4GALT4

Updated on
Share on FacebookTweet on TwitterShare on LinkedInShare on Reddit
Covid-19
Species  Human
Entrez  8702
Human  Mouse
Ensembl  ENSG00000121578
B4GALT4
Aliases  B4GALT4, B4Gal-T4, beta4Gal-T4, beta-1,4-galactosyltransferase 4
External IDs  MGI: 1928387 HomoloGene: 37848 GeneCards: B4GALT4

Beta-1,4-galactosyltransferase 4 is an enzyme that in humans is encoded by the B4GALT4 gene.

This gene is one of seven beta-1,4-galactosyltransferase (beta4GalT) genes. They encode type II membrane-bound glycoproteins that appear to have exclusive specificity for the donor substrate UDP-galactose; all transfer galactose in a beta1,4 linkage to similar acceptor sugars: GlcNAc, Glc, and Xyl. Each beta4GalT has a distinct function in the biosynthesis of different glycoconjugates and saccharide structures. As type II membrane proteins, they have an N-terminal hydrophobic signal sequence that directs the protein to the Golgi apparatus and which then remains uncleaved to function as a transmembrane anchor. By sequence similarity, the beta4GalTs form four groups: beta4GalT1 and beta4GalT2, beta4GalT3 and beta4GalT4, beta4GalT5 and beta4GalT6, and beta4GalT7. The enzyme encoded by this gene appears to mainly play a role in glycolipid biosynthesis. Two alternatively spliced transcript variants have been found for this gene.

References

B4GALT4 Wikipedia


Similar Topics
Tell No One
Alastair Buchan
Tina Mihelić
Topics
 
B
i
Link
H2
L