ICD-O M9833/3 | MeSH D054403 | |
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Specialty Hematology and oncology | ||
B-cell prolymphocytic leukemia is a more aggressive, but still treatable, form of leukemia. The malignant B cells are larger than average. The name is commonly abbreviated B-PLL.
Contents
It can involve deletions from chromosome 11 and chromosome 13.
It has been suggested that some cases may represent a variant of mantle cell lymphoma.
It has a relatively poor prognosis.
Markers
A case has been described as CD20+, CD22+, and CD5-.
It can also be CD5+.
Another case was described as CD45+, CD19+, CD20+, CD5+, HLA-DR+, CD10-, CD23+/-, CD38+ and FMC7-.
Treatment
Splenic irradiation has been used in the treatment.
References
B-cell prolymphocytic leukemia Wikipedia(Text) CC BY-SA