Trisha Shetty (Editor)

Azaserine

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ATC code
  
none

PubChem CID
  
5284344

UNII
  
87299V3Q9W

Molar mass
  
173.127 g/mol

CAS Number
  
115-02-6

ChemSpider
  
16735688

KEGG
  
D03032

Azaserine Azaserine Wikipedia

Azaserine is a naturally occurring serine derivative diazo compound with antineoplastic and antibiotic properties deriving from its action as a purinergic antagonist and structural similarity to glutamine. Azazerine acts by competitively inhibiting glutamine amidotransferase, a key enzyme responsible for glutamine metabolism.

Contents

Azaserine Glentham Life Sciences GA8898 Azaserine 115026

Mechanism of Action

Azaserine inhibits the rate limiting step of the metabolic hexosamine pathway and an irreversibly inhibits γ-glutamyltransferase by acting directly at the substrate-binding pocket. Independent of hexosamine pathway inhibition, azaserine has been demonstrated to protect against hyperglycemic endothelial damage by elevating serum concentrations of manganese-superoxide dismutase, directly reducing the concentration of reactive oxygen species.

Azaserine Azaserine CAS 115026 Cayman Chemical

Azaserine also downregulates the expression of VCAM-1 and ICAM-1 in response to TNF-α, and research indicates that it may have potential in identifying the L-leucine-favoring system transporter in human T-lymphocytes.

Properties

Azaserine LAzaserine C5H7N3O4 ChemSpider

Azaserine has a solubility of 50 mg/mL in water, a melting point of 146-162 °C, a vapor pressure of 1.53x10−10mmHg at 25 °C, and decomposes before melting.

Azaserine AzaserineCN15757CI337ODiazoacetylLserineP165CAS 115026

Azaserine Azaserine ScienceDirect Topics

References

Azaserine Wikipedia


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