Autumn Reeser was born in La Jolla, Southern California, the daughter of Tom and Kim Reeser. She spent her childhood developing a solid foundation for her acting career by playing a wide variety of characters in local musical theater productions, from the age of seven until seventeen. After high school, she moved to Los Angeles and enrolled in UCLA’s competitive theater program, where she studied theater history, acting technique, dance, voice and movement. She also studied acting at the Beverly Hills Playhouse.
In 2001, she started out in Hollywood in an episode of Star Trek: Voyager. Shortly thereafter, she booked guest roles in dramas CSI: Crime Scene Investigation and Cold Case, and moved onto recurring parts in the sitcoms Grounded for Life, Maybe It's Me and Complete Savages.
She rose to fame through her role of Taylor Townsend on the Fox hit series The O.C. (2005-2007). The character was intended to appear in four episodes only, but her role was revised and expanded.
Since the end of The O.C., she appeared as a regular on numerous TV shows: as the agent Lizzy Grant who gives Ari Gold a hard time in seasons 6 and 7 of HBO's Entourage; as Phoebe, a goddess from Greek mythology in CW's Valentine; as Ashley Hastings, a lawyer in TNT's Raising the Bar; as Katie Andrews, Julie Benz's personal assistant in ABC's No Ordinary Family; as Kylie Sinclair, a repentant arms dealer in ABC's Last Resort; as Dr. Gabby Asano, Danny Williams' girlfriend in 6 episodes of CBS's Hawaii Five-0; and as Abby Bruce, John Stamos' rival and love interest in USA Network's Necessary Roughness.
She also appeared occasionally in It's Always Sunny In Philadelphia, Ghost Whisperer, Pushing Daisies, Human Target, Royal Pains, Jane by Design, Hart of Dixie, and others.
In 2015, she took part in three episodes of ABC's The Whispers (including the pilot), produced by Steven Spielberg.
In April 2016, she was the main guest star of an episode of CBS's Criminal Minds: Beyond Borders.
In 2017, she plays pregnant talent agent Leslie Bellcamp on The Arrangement, a new series for the E! channel. The series was renewed for a second season. She also appears on the CBS show Salvation.
Autumn Reeser played in a dozen feature films and television movies, such as the musical The American Mall, the comedy The Girl Next Door, the horror movie Lost Boys: The Tribe, the thriller The Big Bang with Antonio Banderas, the action movie Smokin' Aces 2: Assassins' Ball with Tom Berenger and the detective comedy So Undercover with Miley Cyrus.
In late 2012, she received positive reviews for Hallmark's Love at the Thanksgiving Day Parade, in which she was the main heroine. Shortly after, she appeared in a number of romantic comedies aired on the Hallmark Channel, with leading roles in such TV movies as Midnight Masquerade (October 2014), I Do, I Do, I Do (February 2015), A Country Wedding (June 2015), Valentine Ever After (February 2016), etc.
She appeared in Clint Eastwood's biopic Sully, released in September 2016 and starring Tom Hanks.
In June 2017, she is Jean-Claude Van Damme's leading lady in the action-thriller Kill 'Em All.
She also portrays a paleontologist in the adventure movie Valley of Bones, due to be released theatrically in September 2017.
Since 2006, she has been a member of The WorkJuice Players, a theater troupe primarily known for The Thrilling Adventure Hour, a popular L.A. staged production in the style of old-time radio. She stars in the Amelia Earhart segment, playing the famed pilot, traveling through time; as well as playing a wide variety of other characters in other segments. In 2015, Autumn Reeser and The Thrilling Adventure Hour were invited to perform in New York and Chicago, then Australia (Sydney) and New Zealand (Auckland and Wellington). Other members in the troupe include Paul F. Tompkins, Paget Brewster and Busy Philipps.
An accomplished singer and dancer, Autumn has played in many musicals throughout her life. She also sang in numerous cabarets around Los Angeles, including Upright Cabaret and the acclaimed For The Record: Quentin Tarantino (Show at Barre).
On May 9, 2009, Reeser married writer and director Jesse Warren in Ojai, California. She and Warren have two sons: Finneus 'Finn' James, born May 10, 2011, and Dashiell 'Dash' Ford, born November 25, 2013. In November 2014, Reeser filed for divorce from Warren.
Author and friend Patrick Loubatière wrote a book about her, entitled No Ordinary Girl, published both in English and in French (out of print in French).
In 2015, she was elected to SAG-AFTRA's National and Los Angeles Local Boards.