Specialty endocrinology ICD-9-CM 258.1 DiseasesDB 29690 | ICD-10 E31.0 OMIM 269200 eMedicine med/1868 | |
Autoimmune polyendocrine syndrome type 2, a form of autoimmune polyendocrine syndrome also known as Schmidt's syndrome, or APS-II, is the most common form of the polyglandular failure syndromes. It is heterogeneous and has not been linked to one gene. Rather, patients are at a higher risk when they carry a particular human leukocyte antigen genotype (HLA-DQ2, HLA-DQ8 and HLA-DR4). APS-II affects women to a greater degree than men (75% of cases occur in women).
Contents
Features of this syndrome are:
Symptoms
Symptoms of Addison's disease and Hashimoto's thyroiditis include:
Some researchers favour splitting this syndrome into three distinct syndromes (numbering 2, 3 and 4), but evidence for these distinct combinations is not convincing.
Eponym
It is named for Martin Benno Schmidt (1863 – 1949), a German pathologist.