Antoine McClain played his high school career at Anniston High School in Anniston, Alabama. He was named to the ASWA First-Team All-State after his senior season. He participated in the ESPN/Under Armour All-American game.
He played college football at Clemson. During his time in Clemson, He participated in 2,438 snaps and he played in 54 games and started 41 of them.
In his freshman year, He played in 13 games and was involved in 149 snaps.
In his sophomore year, He started 14 games. He was named the starting offensive guard and recorded 66 knockdown blocks.
In his junior year, he played in 13 games and started all 13 games and he was involved in 704 snaps. He was selected to the Third-team All-ACC and ACC All-Academic Honor Roll.
In his senior year, he played in 14 games and started all 14 games.
On April 30, 2012, After going undrafted in the 2012 NFL Draft, He signed with the Baltimore Ravens. On August 31, 2012, He was released. On September 1, 2012, He re-signed with the team and was assigned to the practice squad. He was released by the Ravens on August 31, 2013.
On September 1, 2013, the Oakland Raiders signed McClain. He was released by the Raiders on October 5, 2013.
On October 7, 2013, McClain was claimed off waivers by the Buffalo Bills. He was released by the Bills on August 30, 2014.
McClain was signed to the practice squad of the New Orleans Saints on September 1, 2014. He was released by the Saints on September 24, 2014.
McClain was signed to the practice squad of the Chicago Bears on November 12, 2014.
On December 31, 2014, McClain was signed by the Arizona Cardinals. On September 5, 2015, he was released by the Cardinals. On September 7, 2015, McClain was brought back to the team and was placed on the practice squad. On January 26, 2016, McClain signed a futures contract with the Arizona Cardinals. On September 3, 2016, he was released by the Cardinals.
On May 17, 2017, McClain was assigned to the Baltimore Brigade.