Siddhesh Joshi (Editor)

Angelika Amon

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Doctoral advisor  Kim Nasmyth
Education  University of Vienna
Name  Angelika Amon
Nationality  Austrian

Angelika Amon httpswwwhhmiorgsitesdefaultfilesWeis20Am
Born  1967 Austria
Institutions  Whitehead Institute (1994–1999) Massachusetts Institute of Technology(1999– )
Alma mater  University of Vienna (B.S.) University of Vienna (Ph.D., 1993)
Known for  Chromosome duplication and cell division
Notable awards  Presidential Early Career Award for Scientists and Engineers (1999) Alan T. Waterman Award (2003) Paul Marks Prize for Cancer Research (2007) NAS Award in Molecular Biology (2008) Ernst Jung Prize (2013)
Awards  NAS Award in Molecular Biology

Citizenship  Austria United States

Angelika amon mit and hhmi part 1 review of the study of aneuploidy


Angelika Amon, Ph.D. (b. 1967) is an Austrian American molecular and cell biologist, and the Kathleen and Curtis Marble Professor in Cancer Research at the Massachusetts Institute of Technology (MIT) in Cambridge, Massachusetts, United States. Amon's research centers on how chromosomes are regulated, duplicated, and partitioned in the cell cycle.

Contents

Angelika Amon IST Austria IST Lecture Angelika Amon

Angelika amon mit and hhmi part 3 aneuploidy disease implications


Background

Angelika Amon Too much of a good thing Cells with extra chromosomes

Amon had an early interest in plant and animal biology as a child, keeping a notebook full of newspaper clippings, and was motivated to study biology after learning about Mendelian genetics in middle school. She received her B.S. from the University of Vienna and continued her doctoral work there under Professor Kim Nasmyth at the Research Institute of Molecular Pathology, receiving a Ph.D. in 1993. She completed a two-year post-doctoral fellowship at the Whitehead Institute in Cambridge, Massachusetts and was subsequently named a Whitehead Fellow for three years. She joined the MIT Center for Cancer Research and MIT's Department of Biology in 1999 and was promoted to full professor in 2007.

Angelika Amon Inside the Lab Angelika Amon PhD YouTube

Amon won a Presidential Early Career Award for Scientists and Engineers in 1998, was named an associate investigator at the Howard Hughes Medical Institute in 2000, and was the 2003 recipient of the National Science Foundation's Alan T. Waterman Award. Amon also shared the 2007 Paul Marks Prize for Cancer Research and won the 2008 National Academy of Sciences Award in Molecular Biology. She was elected to the American Academy of Arts and Sciences in 2017.

Angelika Amon Professor Angelika Amon MIT erhlt Ernst JungPreis fr

Amon is married and has two daughters.

Research

Amon's research has investigated how cells control and organize the segregation of their chromosomes during cell division. More specifically, her research examines the regulation of exit from mitosis, the regulation of the meiotic cell cycle, and effects of aneuploidy on normal physiology and tumorigenesis.

As a student under Nasmyth, Amon demonstrated that CDC28 protein kinase is not required for the metaphase to anaphase transition and CLB2 proteolysis continues until reactivation of CDC28 toward the end of G1.

The Amon lab primarily investigates yeast (Saccharomyces cerevisiae) as a model for understanding the controls that govern cell-cycle progression. As a Whitehead Fellow, her team discovered that CDC20 plays a crucial role in cell division. Her Whitehead team identified an interaction between phosphatase and CDC14 which initiates the exit of cells from mitosis to the G1 phase. Amon's team demonstrated that CDC20 is the target protein in the spindle checkpoint during mitosis.

Amon's more recent work has investigated the regulation of chromosome segregation and how chromosomes are accurately transmitted to gametes in meiosis by examining gene regulatory networks. She identified two regulatory networks (FEAR and MEN) that promote the release of CDC14 which have the potential to identify the mechanisms that control the final stages of the mitotic cell cycle.

Her research group recently created haploid yeast cells containing extra copies of chromosomes and discovered that these aneuploid strains elicit phenotypes independent of the identity of the additional chromosome such as defects in cell cycle progression, increased energy demands, and interference with protein biosynthesis. Amon has also examined trisomy in the mouse as a model of mammalian cell growth and physiology and demonstrated that mammalian aneuploidy results in a stress response analogous to yeast aneuploidy. Amon's aneuploidy research has potential applications to cancer research.

References

Angelika Amon Wikipedia


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