Daddo was born at the Royal Women’s Hospital in Melbourne, Australia on 18 February 1967 to Peter and Brownen Daddo. He began his education at Mt Eliza Primary School and in year seven moved to Peninsula Grammar. After a short stint at the grammar school, the Daddo family moved away from Mt Eliza and continued his education at Millburn Junior High in New Jersey, USA. Returning to Australia, Daddo spent the last two and a half years of his schooling at Melbourne Grammar School. After finishing high school, Daddo began an Arts degree at Monash University in Clayton finishing with majors in politics and history and a minor in sociology.
Andrew has been a longtime presenter on the Seven Network in Australia and has been involved in hosting many Seven specials. He hosted World's Greatest Commercials, which ran from 1995 to 1996 (and also had occasional Cannes Film Festival specials until the late 1990s) as well as the Australian adaptation of Kids Say the Darndest Things. Daddo is one of the travellers on the Globe Trekker series, and is also the author of a number of children's books. He was a presenter on Seven's The Great Outdoors in 1994 and from 2002 to 2008. During the Sydney 2000 Olympics, Daddo and co-presenter Johanna Griggs presented Olympic Sunrise from a leased apartment near Lavender Bay in Sydney which provided the Harbour Bridge and Opera House as waterside backdrops. According to Adam Boland's Brekky Central, in late 2001, producers had created a plan to take over TODAY on Channel Nine as the leader at breakfast which had taken inspiration from Fox America's Fox and Friends. Set to debut in March 2002, the multimillion-dollar production would have its own dedicated studio and fronted by Australian Radio personality Andrew Daddo and Lisa Forrest. However a month before its launch, the network's board axed the idea and believed money could be better spent. American audiences might remember Andrew Daddo from a stint as an MTV VJ in the early 1990s. During the 2008 Beijing Olympics he hosted an Olympics-oriented morning talk show, Yum Cha.
In 2015, Daddo was a contestant on the TV show: I'm a Celebrity...Get Me Out of Here! (Australian TV series).
Since then Daddo has been making commercials for Mitre 10.
He is also a well-known author, having written many books, including Flushed, Good Night Me, Youse Two, It's All Good, Muffin Top, Sprung Again, You're Dropped, Dacked and a few other novels.
Andrew was appointed as presenter of 702 ABC Sydney's evening program, he commenced this position in February 2008. Daddo is the host of the television series The One which premiered on the Seven Network in July, 2008.
In May 2009, Daddo resigned from 702 ABC Sydney to host This Afternoon on the Nine Network. After just two and a half weeks on air, however, This Afternoon was axed by Nine. He then worked as the voice-over narrator for Nine Network's The Apprentice Australia.
Daddo currently resides in the Northern Beaches of Sydney where he is married to Jacqui and has three children, Felix (b.1999), Anouk Bibi (b.2001), and Jasper (b.2004). He is part of a prominent acting family, including brothers Lochie and Cameron. He has an identical twin brother, artist Jamie Daddo, and an older sister, Belinda.
Daddo enjoys the company of animals, keeping a dog named Spud, a Burmese cat, and a chicken named Spite. He has previously owned a dog named Skozza and another, a staffy named Flog. Daddo is an Australian master of the highly strategic Roman board game Nine Men's Morris and easily defeated celebrity chef Julie Goodwin in a series of matches streamed live throughout Australia on the Channel 10 website. Daddo also taught fellow jungle mate, Freddie Flintoff how to knit. Daddo is a supporter of the Melbourne Football Club.