Samiksha Jaiswal

Aconitum carmichaelii

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Kingdom  Plantae
Family  Ranunculaceae
Scientific name  Aconitum carmichaelii
Rank  Species
Order  Ranunculales
Genus  Aconitum
Higher classification  Wolf's bane
Aconitum carmichaelii Aconitum carmichaelii 39Arendsii39 Gardening Impulse
Similar  Wild ginger, Wolf's bane, Glycyrrhiza uralensis, Bai zhu, Wolfiporia extensa

Aconitum carmichaelii variety monkshood


Aconitum carmichaelii syn. A. fischeri, is a species of flowering plant of the genus Aconitum, family Ranunculaceae. It is native to East Asia and eastern Russia. It is commonly known as Chinese aconite, Carmichael's monkshood or Chinese wolfsbane (Chinese: 烏頭附子; pinyin: Wu-tou Fu-zi) (Japanese: 鳥兜 or トリカブト, Torikabuto). It is known in Mandarin as Fu Zi (meaning daughter root, or lateral root) and as Wu Tou (meaning tuberous mother root, or root tuber).

Contents

Aconitum carmichaelii Aconitum carmichaelii 39Arendsii39 Plant amp Flower Stock Photography

Description

Aconitum carmichaelii Issue 48 Article 11 Front Cover Plant Profile Aconitum

Growing to 1.2 m (4 ft) tall by 30 cm (12 in) wide, it is an erect perennial, with 3- to 5-lobed ovate, leathery leaves. Dense panicles of blue flowers are produced in late summer and autumn.

Aconitum carmichaelii Aconitum carmichaelii 39arendsii39 AUTUMN MONKSHOOD Hill Farm Nursery

It is valued as a garden plant, and numerous cultivars have been developed, of which 'Arendsii' and 'Kelmscott' (Wilsonii Group) have gained the Royal Horticultural Society's Award of Garden Merit.

Biological effects

Aconitum carmichaelii httpsuploadwikimediaorgwikipediacommonsthu

All parts of this plant are extremely toxic, and it has historically been used as a poison on arrows. If not prepared properly by a trained person, Aconitum can be deadly when taken internally.

Toxicology

Aconitum carmichaelii FileAconitum carmichaelii var wilsonii 002JPG Wikimedia Commons

Marked symptoms may appear almost immediately, usually not later than one hour, and "with large doses death is almost instantaneous." Death usually occurs within two to six hours in fatal poisoning (20 to 40 mL of tincture may prove fatal). The initial signs are gastrointestinal including nausea, vomiting, and diarrhea. This is followed by a sensation of burning, tingling, and numbness in the mouth and face, and of burning in the abdomen. In severe poisonings pronounced motor weakness occurs and cutaneous sensations of tingling and numbness spread to the limbs. Cardiovascular features include hypotension, sinus bradycardia, and ventricular arrhythmias. Other features may include sweating, dizziness, difficulty in breathing, headache, and confusion. The main causes of death are ventricular arrhythmias and asystole, paralysis of the heart or of the respiratory center. The only post-mortem signs are those of asphyxia.

Aconitum carmichaelii Aconitum carmichaelii 39Kelmscott39 landscape architect39s pages

Treatment of poisoning is mainly supportive. All patients require close monitoring of blood pressure and cardiac rhythm. Gastrointestinal decontamination with activated charcoal can be used if given within one hour of ingestion. The major physiological antidote is atropine, which is used to treat bradycardia. Other drugs used for ventricular arrhythmia include lidocaine, amiodarone, bretylium, flecainide, procainamide, and mexiletine. Cardiopulmonary bypass is used if symptoms are refractory to treatment with these drugs. Successful use of charcoal hemoperfusion has been claimed in patients with severe aconite poisoning.

Aconitum carmichaelii Accession Number 0319401 Aconitum carmichaelii 39Arendsii39

Poisoning may also occur following picking the leaves without wearing gloves; the aconitine toxin is absorbed easily through the skin. In this event, there will be no gastrointestinal effects. Tingling will start at the point of absorption and extend up the arm to the shoulder, after which the heart will start to be affected. The tingling will be followed by unpleasant numbness. Treatment is similar to poisoning caused by oral ingestion.

Aconitum carmichaelii Aconitum carmichaelii 39Kelmscott39 landscape architect39s pages

Aconitine is a potent neurotoxin that opens tetrodotoxin-sensitive sodium channels. It increases influx of sodium through these channels and delays repolarization, thus increasing excitability and promoting ventricular dysrhythmias.

Chemical constituents

  • Aconitine: Raw Fu Zi, 0.004%; prepared Fu Zi, trace/none.
  • Hypaconitine: Raw Fu Zi, 0.12%; prepared Fu Zi, 0.001%
  • Mesaconitine: Raw Fu Zi, 0.033%; prepared Fu Zi, 0.001%
  • The LD50 of aconitine in mice was 0.295 mg/kg SI, and that of the prepared decoction is 17.42 g/k. A lethal dose of aconitine is 3–4 mg.

    Violdelphin is an anthocyanin, a type of plant pigment, found in the purplish blue flower of A. chinense.

    Synonyms

  • Aconitum chinense Paxton [= Aconitum carmichaelii var. truppelianum]
  • Aconitum japonicum var. truppelianum Ulbr. [≡ Aconitum carmichaelii var. truppelianum]
  • References

    Aconitum carmichaelii Wikipedia


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