Rahul Sharma


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Species  Human
Entrez  22809
Human  Mouse
Ensembl  ENSG00000169136
Aliases  ATF5, ATFX, HMFN0395, activating transcription factor 5
External IDs  MGI: 2141857 HomoloGene: 32142 GeneCards: ATF5

Activating transcription factor 5, also known as ATF5, is a protein that, in humans, is encoded by the ATF5 gene.



First described by Nishizawa and Nagata, ATF5 has been classified as a member of the activating transcription factor (ATF)/cAMP response-element binding protein (CREB) family.

ATF5 transcripts and protein are expressed in a wide variety of tissues, in particular, high expression of transcripts in liver. It is also present in a variety of tumor cell types.

ATF5 expression is regulated at both the transcriptional and translational level.

ATF5 is expressed in VZ and SVZ during brain development.

The human ATF5 protein is made up of 282 amino acids.

ATF5 is a transcription factor that contains a bZip domain.


ATF5 has been shown to interact with DISC1 and TRIB3.


ATF5 Wikipedia

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