Supriya Ghosh

ARFGAP1

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Species  Human
Entrez  55738
Human  Mouse
Ensembl  ENSG00000101199
ARFGAP1
Aliases  ARFGAP1, ARF1GAP, HRIHFB2281, ADP ribosylation factor GTPase activating protein 1
External IDs  MGI: 2183559 HomoloGene: 5517 GeneCards: ARFGAP1

ADP-ribosylation factor GTPase-activating protein 1 is an enzyme that in humans is encoded by the ARFGAP1 gene. Two transcript variants encoding different isoforms have been found for this gene.

Contents

Function

The protein encoded by this gene is a GTPase-activating protein (GAP) which associates with the Golgi apparatus and which interacts with ADP-ribosylation factor 1 (ARF1). The encoded protein promotes hydrolysis of ARF1-bound GTP and is required for the dissociation of coat proteins from Golgi-derived membranes and vesicles. Dissociation of the coat proteins is required for the fusion of these vesicles with target compartments. The activity of this protein is stimulated by phosphoinositides and inhibited by phosphatidylcholine.

The protein has two ALPS (amphipatic lipid packing sensor) motifs, that let the protein sense the curvature of the membrane (<30 nm) or lipid packing defects, and in this way evaluate if the vesicule is mature and ready for coat disassembly.

Interactions

ARFGAP1 has been shown to interact with KDELR1 and LRRK2.

References

ARFGAP1 Wikipedia


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