Girish Mahajan

APBA2

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Species  Human
Entrez  321
Human  Mouse
Ensembl  n/a
APBA2
Aliases  APBA2, D15S1518E, HsT16821, LIN-10, MGC:14091, MINT2, X11-BETA, X11L, amyloid beta precursor protein binding family A member 2
External IDs  MGI: 1261791 HomoloGene: 4021 GeneCards: APBA2

Amyloid beta A4 precursor protein-binding family A member 2 is a protein that in humans is encoded by the APBA2 gene.

Contents

Function

The protein encoded by this gene is a member of the X11 protein family. It is a neuronal adaptor protein that interacts with the Alzheimer's disease amyloid precursor protein (APP). It stabilises APP and inhibits production of proteolytic APP fragments including the A beta peptide that is deposited in the brains of Alzheimer's disease patients. This gene product is believed to be involved in signal transduction processes. It is also regarded as a putative vesicular trafficking protein in the brain that can form a complex with the potential to couple synaptic vesicle exocytosis to neuronal cell adhesion.

Interactions

APBA2 has been shown to interact with CLSTN1, RELA and Amyloid precursor protein.

References

APBA2 Wikipedia


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