Kalpana Kalpana


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Species  Human
Entrez  63941
Human  Mouse
Ensembl  ENSG00000125967
Aliases  NECAB3, APBA2BP, EFCBP3, NIP1, STIP3, SYTIP2, XB51, dJ63M2.4, dJ63M2.5, N-terminal EF-hand calcium binding protein 3
External IDs  MGI: 1861721 HomoloGene: 10992 GeneCards: NECAB3

N-terminal EF-hand calcium-binding protein 3 is a protein that in humans is encoded by the NECAB3 gene.

The protein encoded by this gene interacts with the amino-terminal domain of the neuron-specific X11-like protein (X11L), inhibits the association of X11L with amyloid precursor protein through a non-competitive mechanism, and abolishes the suppression of beta-amyloid production by X11L. This protein, together with X11L, may play an important role in the regulatory system of amyloid precursor protein metabolism and beta-amyloid generation. This gene consists of at least 13 exons and its alternative splicing generates at least 2 transcript variants.


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