Girish Mahajan

ADI1

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Species  Human
Entrez  55256
Human  Mouse
Ensembl  n/a
ADI1
Aliases  ADI1, APL1, ARD, Fe-ARD, MTCBP1, Ni-ARD, SIPL, mtnD, HMFT1638, acireductone dioxygenase 1
External IDs  MGI: 2144929 HomoloGene: 75081 GeneCards: ADI1

The human ADI1 gene encodes the enzyme 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase.

Contents

Function

The enzyme belongs to the aci-reductone dioxygenase family of metal-binding enzymes, which are involved in methionine salvage. This enzyme may regulate mRNA processing in the nucleus, and may carry out different functions depending on its localization.

Clinical significance

Diseases associated with ADI1 include Klebsiella, and refsum disease.

ADI1 is capable for supporting hepatitis C virus replication in an otherwise non-permissive cell line. Mouse hepatoma cells coexpressing human CD81 and ADI1/Sip-L supported HCV infection and replication. Human ADI1//Sip-L over-expression in 293 cells enhances cell entry but not replication of HCV.

References

ADI1 Wikipedia


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