Harman Patil


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Species  Human
Entrez  55811
Human  Mouse
Ensembl  ENSG00000143199
Aliases  ADCY10, HCA2, SAC, SACI, Sacy, hsAC, HEL-S-7a, adenylate cyclase 10 (soluble)
External IDs  MGI: 2660854 HomoloGene: 10188 GeneCards: ADCY10

Adenylyl cyclase 10 also known as ADCY10 is an enzyme that, in humans, is encoded by the ADCY10 gene.



The protein encoded by this gene belongs to a distinct class of mammalian adenylyl cyclase that is soluble and insensitive to G protein or forskolin regulation. It is localized in the cytoplasm and is thought to function as a general bicarbonate sensor throughout the body. It may also play an important role in the generation of cAMP in spermatozoa, implying possible roles in sperm maturation through the epididymis, capacitation, hypermotility, and/or the acrosome reaction.

Clinical significance

Mutations in the ADCY10 gene are associated with an increased risk of adsorptive hypercalciuria.


ADCY10 Wikipedia

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