ADARB1

Double-stranded RNA-specific editase 1 is an enzyme that in humans is encoded by the ADARB1 gene.

This gene encodes the enzyme responsible for pre-mRNA editing of the glutamate receptor subunit B by site-specific deamination of adenosines. Studies in rats found that this enzyme acted on its own pre-mRNA molecules to convert an AA dinucleotide to an AI dinucleotide which resulted in a new splice site. Alternative splicing of this gene results in several transcript variants, some of which have been characterized by the presence or absence of an ALU cassette insert and a short or long C-terminal region.

ADAR2 requires the small molecule inositol hexakisphosphate (IP₆) for proper function.