Supriya Ghosh

ADARB1

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Species  Human
Entrez  104
Human  Mouse
Ensembl  ENSG00000197381
ADARB1
Aliases  ADARB1, ADAR2, DRABA2, DRADA2, RED1, adenosine deaminase, RNA specific B1
External IDs  MGI: 891999 HomoloGene: 8280 GeneCards: ADARB1

Double-stranded RNA-specific editase 1 is an enzyme that in humans is encoded by the ADARB1 gene.

This gene encodes the enzyme responsible for pre-mRNA editing of the glutamate receptor subunit B by site-specific deamination of adenosines. Studies in rats found that this enzyme acted on its own pre-mRNA molecules to convert an AA dinucleotide to an AI dinucleotide which resulted in a new splice site. Alternative splicing of this gene results in several transcript variants, some of which have been characterized by the presence or absence of an ALU cassette insert and a short or long C-terminal region.

ADAR2 requires the small molecule inositol hexakisphosphate (IP6) for proper function.

References

ADARB1 Wikipedia


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