Entrez 10057 | Ensembl ENSG00000114770 | |
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Aliases ABCC5, ABC33, EST277145, MOAT-C, MOATC, MRP5, SMRP, pABC11, ATP binding cassette subfamily C member 5 External IDs MGI: 1351644 HomoloGene: 21164 GeneCards: ABCC5 | ||
Multidrug resistance-associated protein 5 is a protein that in humans is encoded by the ABCC5 gene.
Contents
Function
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions in the cellular export of its substrate, cyclic nucleotides. This export contributes to the degradation of phosphodiesterases and possibly an elimination pathway for cyclic nucleotides. Studies show that this protein provides resistance to thiopurine anticancer drugs, 6-mercatopurine and thioguanine, and the anti-HIV drug 9-(2-phosphonylmethoxyethyl)adenine. This protein may be involved in resistance to thiopurines in acute lymphoblastic leukemia and antiretroviral nucleoside analogs in HIV-infected patients. Alternative splicing of this gene has been detected; however, the complete sequence and translation initiation site is unclear.
Interactive pathway map
Click on genes, proteins and metabolites below to link to respective articles.