A V Apkarian

Apkar Vania Apkarian is a professor of physiology, anesthesiology, and physical medicine and rehabilitation at Northwestern University in the Feinberg School of Medicine. He has been a pioneer in the use of Magnetic resonance spectroscopy to study the neurochemistry of the brain and the development of novel analytical approaches to studying consciousness, including the first demonstration of the brain's small-world network properties using fMRI. In 2008, Dr. Apkarian proposed the theory that chronic pain is a form of emotional learning, which popularized the study of reward learning within the pain research field. Dr. Apkarian earned a master's degree in electrical engineering from the University of Southern California and earned a Ph.D. in neuroscience from the State University of New York Upstate Medical University in Syracuse, New York. He is the brother of Vartkess A. Apkarian, a noted chemical physicist and laser spectroscopist at University of California at Irvine.

Contents

• Chronic pain
• Selected media coverage
• References

Dr. Apkarian's early work with primate electrophysiology established that thalamic neurons can be physiologically characterized based on morphology and projections to the cortex, which led to the discovery that the thalamus dynamically encodes nociceptive stimuli in response to features of sensory stimuli. In the 1990's, his research transitioned to human brain imaging-based investigations of pain qualia and neural mechanisms underlying chronic pain. Dr. Apkarian's body of research was pivotal in establishing neuroplasticity as a mechanism of chronic pain, with notable findings including: in 2004 his group first identified grey matter changes related to chronic back pain, in 2008 his group first described resting state network changes in chronic pain patients and white matter abnormalities related to complex regional pain syndrome, and in 2012 his group published the first evidence that functional connectivity between the medial prefrontal cortex and nucleus accumbens prospectively predicts the development of chronic back pain. Much of this work was done in collaboration with Marwan Baliki, a research scientist at the Shirley Ryan Ability Lab (formerly Rehabilitation Institute of Chicago), and Paul Geha, an Assistant Professor of Psychiatry at Yale School of Medicine.

Dr. Apkarian's research has increasingly focused on the translation of neuroimaging findings to improve clinical treatment of chronic pain, include the development of preventative treatments and the strategic use of placebo treatment. This work should hopefully traverse through the alleviation of clinical pain conditions, as well as a more profound theoretical and mechanistic understanding of the brain.

Criticisms of Dr. Apkarian's work include his focus on chronic low back pain, low rates of depression in his clinical cohorts, and emphasis on cortical mechanisms of chronic pain. Nevertheless, his use of rigorous statistical analyses, validation of findings in independent cohorts, replication of findings using multiple imaging modalities, use of longitudinal neuroimaging, and replication of key fMRI findings in rodent models of neuropathic pain have created a consistent body of research.