EC number 3.1.3.72 IntEnz IntEnz view ExPASy NiceZyme view | CAS number 37341-58-5 BRENDA BRENDA entry KEGG KEGG entry | |
In enzymology, a 5-phytase (EC 3.1.3.72) is an enzyme that catalyzes the chemical reaction
Contents
myo-inositol hexakisphosphate + H2OThus, the two substrates of this enzyme are myo-inositol hexakisphosphate and H2O, whereas its two products are 1L-myo-inositol 1,2,3,4,6-pentakisphosphate and phosphate.
This enzyme belongs to the family of hydrolases, specifically those acting on phosphoric monoester bonds. The systematic name of this enzyme class is myo-inositol-hexakisphosphate 5-phosphohydrolase.
Prevalence
Of the hundreds of phytase enzymes that have been characterized in the literature, only two have been characterized as 5-phytases. A histidine acid phosphatases purified from lily pollen and a protein tyrosine phosphatase-like phytase from Selenomonas ruminantium subsp. lactilytica were both found to have specificity for the 5-phosphate position of myo-inositol hexakisphosphate.
Structural studies
As of late 2007, only the phytase purified from lily pollen had its structure solved, with PDB accession codes 1U24, 1U25, 1U26, 2B4O, 2B4P, and 2B4U.