The Florida Marlins made Adrian Gonzalez of Eastlake High School in Chula Vista, California the first overall selection in the 2000 First-Year Player Draft. Gonzalez, who was rated as the best pure high school hitter in the draft by Baseball America, was the first high school first baseman taken first overall since the New York Yankees chose Ron Blomberg in 1967. In his senior year, Gonzalez hit .645 with 13 home runs and 34 RBI.
Among the college players chosen was David Parrish, son of former major leaguer Lance Parrish, by the New York Yankees with the 28th pick. In addition, David Espinosa, a high school shortstop from Miami, Florida, became the first RBI (Reviving Baseball in Inner Cities) alumnus ever selected in the first round of the draft.
Infielder Xavier Nady, second round pick of the San Diego Padres out of the University of California, went straight to the Major Leagues in 2000. He became the 19th player to do so since the draft started in 1965.
Xavier Nady, 2nd round, 49th overall by the San Diego PadresChris Narveson, 2nd round, 53rd overall by the St. Louis CardinalsBrian Tallet, 2nd round, 55th overall by the Cleveland IndiansJoel Hanrahan, 2nd round, 57th overall by the Los Angeles DodgersManny Delcarmen, 2nd round, 62nd overall by the Boston Red SoxChad Qualls, 2nd round, 67th overall by the Houston AstrosGrady Sizemore, 3rd round, 75th overall by the Montreal ExposMichael Morse, 3rd round, 82nd overall by the Chicago White SoxChris Young, 3rd round, 89th overall by the Pittsburgh PiratesTodd Wellemeyer, 4th round, 103rd overall by the Chicago CubsDavid DeJesus, 4th round, 104th overall by the Kansas City RoyalsCliff Lee, 4th round, 105th overall by the Montreal ExposYadier Molina, 4th round, 113th overall by the St. Louis CardinalsLaynce Nix, 4th round, 124th overall by the Texas RangersGarrett Atkins, 5th round, 137th overall by the Colorado RockiesBobby Jenks, 5th round, 140th overall by the Anaheim AngelsTaylor Buchholz, 6th round, 175th overall by the Philadelphia PhilliesAaron Hill, 7th round, 200th overall by the Anaheim AngelsDontrelle Willis, 8th round, 223rd overall by the Chicago CubsNick Masset, 8th round, 244th overall by the Texas RangersBrandon Webb, 8th round, 249th overall by the Arizona DiamondbacksEdwin Encarnación, 9th round, 274th overall by the Texas RangersClint Barmes, 10th round, 287th overall by the Colorado RockiesBrad Hawpe, 11th round, 317th overall by the Colorado RockiesCorey Hart, 11th round, 321st overall by the Milwaukee BrewersFreddy Sanchez, 11th round, 332nd overall by the Boston Red SoxJason Kubel, 12th round, 342nd overall by the Minnesota TwinsBrian Bruney, 12th round, 369th overall by the Arizona DiamondbacksRyan Church, 14th round, 426h overall by the Cleveland IndiansJames Shields, 16th round, 466th overall by the Tampa Bay Devil RaysJosh Willingham, 17th round, 491st overall by the Florida MarlinsPaul Maholm, 17th round, 492nd overall by the Minnesota Twins, but did not signMike Napoli, 17th round, 500th overall by the Anaheim AngelsRich Harden, 17th round, 510th overall by the Oakland AthleticsMichael Bourn, 19th round, 577th overall by the Houston Astros, but did signJosé Bautista, 20th round, 599th overall by the Pittsburgh PiratesJason Bay, 22nd round, 645th overall by the Montreal ExposJason Hammel, 23rd round, 686th overall by the Seattle Mariners, but did not signNate McLouth, 25th round, 749th overall by the Pittsburgh PiratesChad Cordero, 26th round, 769th overall by the San Diego Padres, but did not signIan Snell, 26th round, 779th overall by the Pittsburgh PiratesIan Kinsler, 29th round, 879th overall by the Arizona Diamondbacks, but did not signAdam LaRoche, 29th round, 880th overall by the Atlanta BravesBrian Wilson, 30th round, 906th overall by the Cleveland Indians, but did not signNick Blackburn, 34th round, 1006th overall by the Tampa Bay Devil Rays, but did not signRussell Martin, 35th round, 1035th overall by the Montreal Expos, but did not signTim Stauffer, 36th round, 1074th overall by the Baltimore Orioles, but did not signScott Baker, 36th round, 1079th overall by the Pittsburgh Pirates, but did not signTom Gorzelanny, 38th round, 1132nd overall by the Chicago White Sox, but did not signLuke Scott, 45th round, 1327th overall by the Tampa Bay Devil Rays, but did not signDavid Murphy, 50th round, 1439th overall by the Anaheim Angels, but did not signMewelde Moore, 4th round, 109th overall by the San Diego PadresMichael Vick, 30th round, 887th overall by the Colorado Rockies, but did not signRonnie Brown, 42nd round, 1253rd overall by the Seattle Mariners, but did not signFreddie Mitchell, 50th round, 1441st overall by the Chicago White Sox, but did not signBrooks Bollinger, 50th round, 1443rd overall by the Los Angeles Dodgers, but did not sign