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2 Methylimidazole

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Molar mass  82.1 g/mol
Boiling point  270 °C
Melting point  145 °C
Appearance  white or colorless solid
2-Methylimidazole wwwsigmaaldrichcomcontentdamsigmaaldrichstr

Lag synthesis zno and 2 methylimidazole into zif 8


2-Methylimidazole is an organic compound that is structurally related to imidazole with the chemical formula CH3C3H2N2H. It is a white or colorless solid that is highly soluble in polar organic solvents. It is a precursor to a range of drugs and is a ligand in coordination chemistry.

Contents

Ilag synthesis of zif 8 from zno and 2 methylimidazole


Synthesis and reactions

It is prepared by condensation of glyoxal, ammonia, and acetaldehyde, a Radziszewski reaction. Nitration gives 5-nitro derivative.

2-Methylimidazole is a sterically hindered imidazole that is used to similuate the coordination of histidine to heme complexes. It can be deprotonated to make imidazolate-based coordination polymers.

Applications

2-Methylimidazole is a precursor to the several members of the nitroimidazole antibiotics that are used to combat anaerobic bacterial and parasitic infections.

  • Nitroimidazole antibiotics and antiprotozoals containing 2-methylimidazole cores:
  • Safety

    It has low toxicity with an LD50 (rat, oral) of 1300 mg/kg, but it is strongly irritating to the skin and eyes.

    References

    2-Methylimidazole Wikipedia


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