Molar mass 82.1 g/mol Boiling point 270 °C | Melting point 145 °C Appearance white or colorless solid | |
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Lag synthesis zno and 2 methylimidazole into zif 8
2-Methylimidazole is an organic compound that is structurally related to imidazole with the chemical formula CH3C3H2N2H. It is a white or colorless solid that is highly soluble in polar organic solvents. It is a precursor to a range of drugs and is a ligand in coordination chemistry.
Contents
Ilag synthesis of zif 8 from zno and 2 methylimidazole
Synthesis and reactions
It is prepared by condensation of glyoxal, ammonia, and acetaldehyde, a Radziszewski reaction. Nitration gives 5-nitro derivative.
2-Methylimidazole is a sterically hindered imidazole that is used to similuate the coordination of histidine to heme complexes. It can be deprotonated to make imidazolate-based coordination polymers.
Applications
2-Methylimidazole is a precursor to the several members of the nitroimidazole antibiotics that are used to combat anaerobic bacterial and parasitic infections.
Safety
It has low toxicity with an LD50 (rat, oral) of 1300 mg/kg, but it is strongly irritating to the skin and eyes.