25 September - Secret Treaty of Bruges signed by Emperor Charles V and Cardinal Wolsey agreeing to declare war on France in 1523.
11 October - Pope Leo X bestows Henry VIII with the title Defender of the Faith for his work Assertio Septem Sacramentorum (The Assertion of the Seven Sacraments) attacking the teachings of Martin Luther.
1522
Late May - England presents an ultimatum to France and Scotland.
19 June - Charles V visits England for six weeks and signs the Treaty of Windsor pledging a joint invasion of France, bringing England into the Italian War of 1521–1526. Henry VIII has the Round Table at Winchester Castle repainted with his own image for the visit.
July - The English army attacks Brittany and Picardy from Calais, burning and looting the countryside.
Anthony Fitzherbert publishes Diversité de courtz et leur jurisdictions, The Boke of Surveyinge and Improvements and The Boke of Husbandrie (the first work on agriculture published in England).
1524
25 May - Henry VIII and Charles V form an alliance to support Charles III, Duke of Bourbon in his dispute with Francis I of France.
Henry VIII receives a "box of marmalade" from Mr Hull of Exeter.
1525
June - The Amicable Grant, a form of poll tax imposed without the consent of Parliament, abandoned.
16 June - Henry VIII creates his 6-year old illegitimate son Henry Fitzroy Duke of Richmond and Somerset.
July - Wolsey founds Cardinal College, Oxford.
14 August - Peace is agreed between England and France.
The first of several debasements of coinage, reducing the size of silver coins, and raising the value of the gold sovereign.
William Tyndale's English translation of the Bible, printed in Germany, reaches England. In October, Cuthbert Tunstall, Bishop of London, attempts to collect all the copies in his diocese and burn them.
2 October - William Tyndale's The Obedience of a Christian Man (The Obedience of a Christen man, and how Christen rulers ought to govern) is printed in Antwerp for clandestine distribution in England.
27 August - Henry VIII accedes to the Treaty of Cambrai.
26 October - Cardinal Wolsey falls from power due to his failure to prevent Habsburg expansion in Europe and obtain a divorce for Henry VIII. Thomas More succeeds him as Lord Chancellor.
