Puneet Varma (Editor)

1,2,4 Triazole

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Formula  C2H3N3
Appearance  white solid
Boiling point  260 Â°C
1,2,4-Triazole httpsuploadwikimediaorgwikipediacommonsthu
Related compounds  1,2,3-triazole imidazole

Dr rapolu kiran kumar 3 5 dinitro 1h 1 2 4 triazole 3 5 diamino 1h 1 2 4 triazole diazotisation


1,2,4-Triazole is one of a pair of isomeric chemical compounds with molecular formula C2H3N3, called triazoles, which have a five-membered ring of two carbon atoms and three nitrogen atoms. 1,2,4-Triazole is a basic aromatic heterocycle. 1,2,4-Triazole derivatives find use in a wide variety of applications, most notably as antifungals such as fluconazole and itraconazole.

Contents

1,2,4-Triazole File124Triazole structuresvg Wikipedia

1,2,4-Triazoles can be prepared using the Einhorn–Brunner reaction or the Pellizzari reaction.

Unsubstituted 1,2,4-triazole can be prepared from thiosemicarbazide by acyation with formic acid and subsequent cyclization of 1-formyl-3-thiosemicarbazide into 1,2,4-triazole-3(5)-thiol; oxydation of thiol by nitric acid yelds 1,2,4-triazole.

1,2,4-Triazole 4Amino4H124triazole CAS 584134 SCBT

The ring structure appears in certain N-heterocyclic carbenes.

Application

  • Used in the preparation of Rizatriptan, Letrozole, Vorozole, & Posaconazole.

  • 1,2,4-Triazole substancetooltipashxid2165
    1,2,4-Triazole 5Phenyl1H124triazole3thiol 95 SigmaAldrich
    1,2,4-Triazole 3Amino124triazole5thiol 95 SigmaAldrich
    1,2,4-Triazole 1H124Triazole1acetic acid C4H5N3O2 ChemSpider
    1,2,4-Triazole 124Triazole C2H3N3 ChemSynthesis
    1,2,4-Triazole

    References

    1,2,4-Triazole Wikipedia


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