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Zydis

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Zydis is a technology used to manufacture orally disintegrating tablets developed by R.P. Scherer Corporation. Zydis tablets dissolve in the mouth within 3 seconds.

Contents

New tricks for old dogs zydis oral dissolving technology


History

Zydis technology was developed by R.P. Scherer Corporation (currently owned by Catalent Pharma Solutions) in 1986. The technology's first commercial application was in August, 1993, when a new dosage form of Pepcidine (famotidine) from Merck & Co. was launched in Sweden.

In November 1993 Imodium Lingual (loperamide) from Janssen Pharmaceutica was released in Germany with Zydis technology.

In December, 1996, the Food and Drug Administration approved the first prescription drug with Zydis technology sold in the U.S., Claritin RediTabs (loratadine) from Schering-Plough.

Technology

A Zydis tablet is produced by lyophilizing or freeze-drying the drug in a matrix usually consisting of gelatin. The resulting product is very lightweight and fragile, and must be dispensed in a special blister pack.

Amipara et al., in their article "Oral disintirating tablet of antihypertensive drug" explain the technology's limitations:

The Zydis formulations consist of a drug physically trapped in a water-soluble matrix (saccharine mixture and polymer), which is freeze dried to produce a product that dissolves rapidly when placed in mouth. The ideal candidate for Zydis technology should be chemically stable and insoluble and particle size preferably less than 50 micron.

Advantages

Zydis tablets are:

  • convenient for the patients who have difficulty in swallowing (children, old people, bed-ridden and psychiatric patients);
  • fast to absorb;
  • don't require water to consume;
  • have good taste (mouth feel);
  • don't provoke choking or suffocation;
  • have high microbial resistance ("due to the low moisture content in the final product, the Zydis formulation does not allow microbial growth").

    • Disadvantages

    Disadvantages include:

  • increased price due to cost-intensive production;
  • sensitivity to moisture (tablets can degrade at higher humidity);
  • poor physical resistance (easy to break);
  • limited ability to incorporate higher concentrations of active drug.

    • Fast dissolving drugs with Zydis technology

    Data from "Fast Disintegrating Drug Delivery Systems: A Review with Special Emphasis on Fast Disintegrating Tablets" (2013).

    References

    Zydis Wikipedia
    (Text) CC BY-SA