Entrez 7514 | Ensembl ENSG00000082898 | |
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Aliases XPO1, CRM1, emb, exp1, exportin 1 External IDs MGI: 2144013 HomoloGene: 2554 GeneCards: XPO1 | ||
Exportin 1 (XPO1), also known as chromosomal maintenance 1 (CRM1), is an eukaryotic protein that mediates the nuclear export of proteins, rRNA, snRNA, and some mRNA.
Contents
Function
Exportin 1 mediates leucine-rich nuclear export signal (NES)-dependent protein transport. Exportin 1 specifically inhibits the nuclear export of Rev and U snRNAs. It is involved in the control of several cellular processes by controlling the localization of cyclin B, MPAK, and MAPKAP kinase 2. This protein also regulates NFAT and AP-1.
Interactions
XPO1 has been shown to interact with:
References
XPO1 Wikipedia(Text) CC BY-SA