Wynne is a surname of Welsh origin. Notable people with the surname include:
Angus G. Wynne (1914–79), an American businessman, founder of Six Flags theme parksArthur Wynne (1862–1945), an English-American inventor of the crossword puzzleBill Wynne (born 1922), an American photographer and writerDavid Wynne (composer) (1900–83), a Welsh composerDavid Wynne (sculptor) (born 1926), a British sculptorEd Wynne (born 1961), a British musician and son of sculptor David WynneEd Wynne (saxophonist), musician with the Doobie BrothersEdward Wynne (colonial governor)(fl. 1621–26), an early Newfoundland colonist, proprietary governor of the Ferryland colony from 1621 to 1626Edward Wynne (chancellor) (1681–1755), Welsh lawyer and landownerEdward Wynne (jurist) (1734–1784), English lawyer and scholarEdward Wynne-Pendarves (1775–1853), British politicianEllis Wynne (1671–1734), a Welsh clergymanEmanuel Wynne (fl. c. 1700), a French pirateFrank Wynne (born 1962), an Irish translator and writerGiustiniana Wynne (1737–1791), an Anglo-Venetian author, A.K.A Countess Orsini-Rosenberg of AustriaGraeme Chamley Wynne (born 1889), a British military historianGreville Wynne (1919–90), a British spyIan Wynne (born 1973), a British flatwater canoeistJay Wynne (fl. since 1994), a British television & radio weather forecasterJohn Wynne (ice hockey) (born 1971), a Canadian ice hockey defencemanKathleen Wynne (fl. since 1980), a Canadian politician - Premier of OntarioKhalid Shameem Wynne, a Pakistani generalLyman Wynne (1925–2007), an American psychiatrist and psychologistMadeline Yale Wynne (1847−1918), an American artist, teacher, and philanthropist.Marvell Wynne (baseball player) (born 1959), an American baseball outfielderMarvell Wynne (soccer) (born 1986), an American football playerMichael Wynne (born 1944), an American businessman, Secretary of the Air ForceMichael James Wynne (M.J.Wynne), a botanistOwen Wynne (disambiguation), several people of this namePhilippé Wynne (1941–84), an American R&B vocalistRobert Wynne (1851–1922), an American politicianRobert Wynne (Virginia politician) (1622–75), a Virginia colonial politician, Speaker of the Virginia House of BurgessesSusan Wynne (fl. 1987–94), an American figure skaterWilliam Watkin Edward Wynne (1801–1880), Welsh politician and antiquarian