Wilkerson is a surname. Notable people with the surname include:
Brad Wilkerson (born 1977), American baseball player
Cathlyn Platt Wilkerson (born 1945), American radical and member of the Weather Underground
David Wilkerson (1931–2011), American evangelist
Eric Wilkerson (born 1966), American football player
Gerald Eugene Wilkerson (born 1939), Auxiliary Bishop of the Roman Catholic Archdiocese of Los Angeles
Isaiah Wilkerson (born 1990), American basketball player
James Herbert Wilkerson (1869–1948), US federal judge
Jerry O. Wilkerson (1943–2007), American painter
Kimberly Wilkerson, former Miss Wyoming
Lawrence Wilkerson (born 1945), U.S. Army officer, deputy to Colin Powell
Mark Wilkerson (born 1976), lead singer and guitarist of the rock band Course of Nature
Muhammad Wilkerson (born 1989), American football Defensive End for the New York Jets of the National Football League
Nathaniel P. Wilkerson (born 1972), Gitksan artist from British Columbia, Canada
Pinkie C. Wilkerson (1948–2000), African American Louisiana state representative
Ponchai Wilkerson (1971–2000), American murderer who was executed in Texas
Robert King Wilkerson, Black Panther Party member
Tichi Wilkerson Kassel (1926–2004), American film personality and the publisher of The Hollywood Reporter
Tim Wilkerson (born 1960), NHRA drag racer
Tyler Wilkerson (born 1988), American basketball player
Wallace Wilkerson (c. 1834–1879), American murderer whose execution by firing squad in Utah was botched
William Wilkerson (1890–1962), founder of The Hollywood Reporter, Ciro's, and the Flamingo Hotel
Fictional characters:
Wilkerson, the family name in the television show Malcolm in the Middle